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Article

Investigation of DNA polymorphisms in SMAD genes for genetic predisposition to diabetic nephropathy in patients with type 1 diabetes mellitus.

Diabetologia - 1 May 2009

McKnight A J, Woodman A M, Parkkonen M, Patterson C C, Savage D A, Forsblom C, Pettigrew K A, Sadlier D, Groop P H, Maxwell A P

Abstract excerpt

AIMS/HYPOTHESIS: SMAD proteins are involved in multiple signalling pathways and are key modulators of gene expression. We hypothesised that genetic variation in selected SMAD genes contributes to susceptibility to diabetic nephropathy. METHODS: We selected 13 haplotype tag (ht) single nucleotide polymorphisms (SNPs) from 67 variants identified by resequencing the SMAD2 and SMAD3 genes. For SMAD1, SMAD4 and SMAD5...

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Share to Blood Pressure
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Kidney Failure, Chronic

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Source

Identifiers

PMID: 19247629
DOI: 10.1007/s00125-009-1281-3

Genes

SMAD1
SMAD5
SMAD2
SMAD3
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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