The association between vitamin D receptor gene polymorphism FokI and type 2 diabetic kidney disease and its molecular mechanism: a case control study.

doi:10.1186/s12920-024-02061-9

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The association between vitamin D receptor gene polymorphism FokI and type 2 diabetic kidney disease and its molecular mechanism: a case control study.

BMC medical genomics - 18 Dec 2024

Zhao Yaping, Liu Zehui, Feng Shiyu, Yang Rong, Ran Zhenqin, Zhu Rong, Ma Lijuan, Wang Zizhou, Chen Lixin, Han Rui

Abstract excerpt

BACKGROUND: The role of the vitamin D receptor single nucleotide polymorphism FOKI (VDR-FOKI) (rs2228570) in genetic susceptibility to type 2 diabetic kidney disease (T2DKD) remains uncertain. This study investigated the relationship between VDR-FOKI and T2DKD within the Chinese Plateau Han population and analyzed the underlying mechanisms. METHODS: A total of 316 subjects were enrolled, including 44 healthy...

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PMID: 39696279
DOI: 10.1186/s12920-024-02061-9
PMCID: PMC11658427

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