Article
Analysis of the vitamin D receptor gene sequence variants in type 1 diabetes.
Diabetes - 1 Oct 2004
Nejentsev Sergey, Cooper Jason D, Godfrey Lisa, Howson Joanna M M, Rance Helen, Nutland Sarah, Walker Neil M, Guja Cristian, Ionescu-Tirgovişte Constantin, Savage David A, Undlien Dag E, Rønningen Kjersti S, Tuomilehto-Wolf Eva, Tuomilehto Jaakko, Gillespie Kathleen M, Ring Susan M, Strachan David P, Widmer Barry, Dunger David, Todd John A
Abstract excerpt
Vitamin D is known to modulate the immune system, and its administration has been associated with reduced risk of type 1 diabetes. Vitamin D acts via its receptor (VDR). Four single nucleotide polymorphisms (SNPs) of the VDR gene have been commonly studied, and evidence of association with type 1 diabetes has been reported previously. We sequenced the VDR gene region and developed its SNP map. Here we analyzed...
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