Article
Association between angiotensin-converting enzyme gene polymorphisms and diabetic nephropathy: case-control, haplotype, and family-based study in three European populations.
Journal of the American Society of Nephrology : JASN - 1 Apr 2007
Hadjadj Samy, Tarnow Lise, Forsblom Carol, Kazeem Gbenga, Marre Michel, Groop Per-Henrik, Parving Hans-Henrik, Cambien François, Tregouet David A, Gut Ivo G, Théva Alexandre, Gauguier Dominique, Farrall Martin, Cox Roger, Matsuda Fumihiko, Lathrop Mark, Hager-Vionnet Nathalie
Abstract excerpt
Angiotensin 1-converting enzyme gene (ACE) is a risk factor for diabetic nephropathy (DN) in patients with type 1 diabetes. The selection of this candidate gene is supported by cross-sectional and follow-up studies, but no convincing family-based studies are available. Recruited were 1057 patients (with DN: persistent albuminuria with or without renal failure) and 1127 control subjects (long-standing [> or =15...
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