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Article

Light chain somatic mutations change thermodynamics of binding and water coordination in the HyHEL-10 family of antibodies.

Molecular immunology - 1 Dec 2009

Acchione Mauro, Lipschultz Claudia A, DeSantis Morgan E, Shanmuganathan Aranganathan, Li Mi, Wlodawer Alexander, Tarasov Sergey, Smith-Gill Sandra J

Abstract excerpt

Thermodynamic and structural studies addressed the increased affinity due to L-chain somatic mutations in the HyHEL-10 family of affinity matured IgG antibodies, using ITC, SPR with van't Hoff analysis, and X-ray crystallography. When compared to the parental antibody H26L26, the H26L10 and H26L8...

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Identifiers

PMID: 19781789
DOI: 10.1016/j.molimm.2009.08.018
PMCID: PMC6291001

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SPR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19781789-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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