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Article

The R1441C mutation alters the folding properties of the ROC domain of LRRK2.

Biochimica et biophysica acta - 1 Dec 2009

Li Yongchao, Dunn Laura, Greggio Elisa, Krumm Brian, Jackson Graham S, Cookson Mark R, Lewis Patrick A, Deng Junpeng

Abstract excerpt

LRRK2 is a 250 kDa multidomain protein, mutations in which cause familial Parkinson's disease. Previously, we have demonstrated that the R1441C mutation in the ROC domain decreases GTPase activity. Here we show that the R1441C alters the folding properties of the ROC domain, lowering its thermodynamic stability. Similar to small GTPases, binding of different guanosine nucleotides alters the stability of the ROC...

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Identifiers

PMID: 19781641
DOI: 10.1016/j.bbadis.2009.09.010
PMCID: PMC2846748

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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