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Article

Irsogladine maleate, a gastric mucosal protectant, suppresses intestinal polyp development in Apc-mutant mice.

Oncotarget - 23 Feb 2016

Onuma Wakana, Tomono Susumu, Miyamoto Shinngo, Fujii Gen, Hamoya Takahiro, Fujimoto Kyoko, Miyoshi Noriyuki, Fukai Fumio, Wakabayashi Keiji, Mutoh Michihiro

Abstract excerpt

This study aimed to identify gastric mucosal protectants that suppress intestinal tumorigenesis in a mouse model. We chose six gastric mucosal protectants (ecabet sodium hydrate, irsogladine maleate, rebamipide, sofalcone, teprenone and troxipide) and examined their effects on the activity of oxidative stress-related transcriptional factors, including AP-1, NF-jB, NRF2, p53 and STAT3, in Caco-2 cells using a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26840084
DOI: 10.18632/oncotarget.7082
PMCID: PMC4890993

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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