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Article

Senescence as a mode of tumor suppression.

1 Jun 1991

Abstract excerpt

Two independent lines of experimental evidence are presented in support of the hypothesis that senescence is a normal mechanism of tumor suppression, a homeostatic device designed through evolution to limit cell proliferation irreversibly and thereby to protect the organism against cancer. One set of experiments uses normal human foreskin fibroblasts, transfected at early passage with SV40 DNA and subsequently...

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Identifiers

PMID: 1663451
DOI: 10.1289/ehp.919359

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