Article
The ability of E1A to rescue ras-induced premature senescence and confer transformation relies on inactivation of both p300/CBP and Rb family proteins.
Cancer research - 15 Sept 2005
Deng Qingdong, Li Yilei, Tedesco Donato, Liao Rong, Fuhrmann Gerhard, Sun Peiqing
Abstract excerpt
In primary cells, oncogenic ras induces a stable growth arrest known as premature senescence. Ras-induced premature senescence is considered as a tumor-suppressing defense response that needs to be bypassed before oncogenic potential ras can be revealed. To gain insights into the mechanism of senescence bypass during oncogenic transformation, we dissected the activities of an adenoviral oncoprotein E1A, which is...
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