Article
Genetic factors are relevant and independent determinants of antihypertensive drug effects in a multiracial population.
American journal of hypertension - 1 Dec 2009
van Rijn-Bikker Petra C, Mairuhu Gideon, van Montfrans Gert A, Sijbrands Eric J G, Zwinderman Aeilko H, Guchelaar Henk-Jan, Koopmans Richard P
Abstract excerpt
BACKGROUND: The success of antihypertensive drugs may be improved by better prediction of their efficacy in individual patients. The objective of our study was to determine whether genetic variation predicts the individual systolic blood pressure (SBP) response to antihypertensive drugs and to assess to what extent the individual treatment response could be explained by the combined effects of known demographic,...
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