Article
Molecular clones of SIVsm and SIVagm: experimental infection of macaques and African green monkeys.
Journal of medical primatology - 1 Jan 1990
Johnson P R, Goldstein S, London W T, Fomsgaard A, Hirsch V M
Abstract excerpt
We have investigated the ability of biologically-active proviral molecular clones of SIVsm and SIVagm to infect rhesus macaques, pig-tail macaques, and African green monkeys. Two clones of SIVsm were individually inoculated into four rhesus and four pig-tail macaques. All eight macaques became infected, and two have experienced a significant decline in absolute numbers of circulating CD4+ cells. None of three...
Topics
- Acquired Immunodeficiency Syndrome
- Animals
- CD4-Positive T-Lymphocytes
- Chlorocebus aethiops
- Cloning, Molecular
- Disease Models, Animal
- Gene Frequency
- Genetic Variation
- Macaca mulatta
- Macaca nemestrina