HIV-1–induced AIDS in monkeys

doi:10.1126/science.1250761

Article

HIV-1–induced AIDS in monkeys

20 Jun 2014

Abstract excerpt

Primate lentiviruses exhibit narrow host tropism, reducing the occurrence of zoonoses but also impairing the development of optimal animal models of AIDS. To delineate the factors limiting cross-species HIV-1 transmission, we passaged a modified HIV-1 in pigtailed macaques that were transiently depleted of CD8(+) cells during acute infection. During adaptation over four passages in macaques, HIV-1 acquired the...

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