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Article

Do the mutations of C1GALT1C1 gene play important roles in the genetic susceptibility to Chinese IgA nephropathy?

BMC medical genetics - 24 Sept 2009

Li Gui-Sen, Nie Guang-Jun, Zhang Hong, LV Ji-Cheng, Shen Yan, Wang Hai-Yan

Abstract excerpt

BACKGROUND: The deficiency of beta1,3 galactose in hinge region of IgA1 molecule played a pivotal role in pathogenesis of IgA nephropathy (IgAN). Cosmc, encoded by C1GALT1C1 gene, was indispensable to beta1,3 galactosylation of IgA1. We designed a serial study to investigate the relationship between the mutations of C1GALT1C1 gene and the genetic susceptibility to IgAN. METHODS: Nine hundred and thirty-eight...

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Identifiers

PMID: 19778426
DOI: 10.1186/1471-2350-10-101
PMCID: PMC2761879

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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