Article
Genetic variant of C1GalT1 contributes to the susceptibility to IgA nephropathy.
Journal of nephrology - 1 Jan 2000
Pirulli Doroti, Crovella Sergio, Ulivi Sheila, Zadro Cristina, Bertok Sara, Rendine Sabina, Scolari Francesco, Foramitti Marina, Ravani Pietro, Roccatello Dario, Savoldi Silvana, Cerullo Giuseppina, Lanzilotta Salvatore Giovanni, Bisceglia Luigi, Zelante Leopoldo, Floege Jurgen, Alexopoulos Epstathios, Kirmizis Dimitrios, Ghiggeri Gian Marco, Frascà Giovanni, Schena Francesco Paolo, Amoroso Antonio
Abstract excerpt
BACKGROUND: IgA nephropathy (IgAN) is a common form of primary glomerulonephritis characterized by diffuse glomerular mesangial IgA1 deposition that leads to mesangial proliferation and chronic glomerular inflammation. Analyses of serum IgA1 from IgAN patients revealed an abnormal galactosylation of the O-linked carbohydrate moieties of IgA that may be a result of altered activity of core 1...
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