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Article

Linkage disequilibrium detected between dystrophia myotonica and APOC2 locus in the Finnish population.

Human genetics - 1 Oct 1990

Nokelainen P, Alanen-Kurki L, Winqvist R, Falck B, Somer H, Leisti J, Johnson K, Savontaus M L, Peltonen L

Abstract excerpt

Three polymorphic loci APOC2, CKMM and p134C were used to haplotype 15 Finnish dystrophia myotonica (DM) families representing about one third of all DM patients in this isolated population. Compound APOC2 and CKMM haplotypes reveal linkage disequilibrium: 90% of DM chromosomes co-occur with the haplotypes that occur in 31% of normal chromosomes only. The same disequilibrium is present when only polymorphisms...

Topics

Alleles
Chromosomes, Human, Pair 19
DNA Probes
Finland
Gene Frequency
Genetic Markers
Haplotypes
Humans
Linkage Disequilibrium
Myotonic Dystrophy
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Restriction Fragment Length

Statistics as Topic

Source

Identifiers

PMID: 1977684
DOI: 10.1007/BF00194234

Genes

APOC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1977684-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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