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Article

Linkage disequilibrium in isolated populations: Finland and a young sub-population of Kuusamo.

European journal of human genetics : EJHG - 1 Aug 2000

Varilo T, Laan M, Hovatta I, Wiebe V, Terwilliger J D, Peltonen L

Abstract excerpt

Linkage disequilibrium (LD), non-random association of alleles at closely linked chromosomal loci, has been used as a tool in the identification of disease alleles, and this has led to an improved understanding of pathology in many monogenic Mendelian human diseases. We are currently moving from the mapping and identification of monogenic disease loci to attempts at identifying loci involved in predisposition to...

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PMID: 10951523
DOI: 10.1038/sj.ejhg.5200482

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