Article
Localization of the EPM1 gene for progressive myoclonus epilepsy on chromosome 21: linkage disequilibrium allows high resolution mapping.
Human molecular genetics - 1 Aug 1993
Lehesjoki A E, Koskiniemi M, Norio R, Tirrito S, Sistonen P, Lander E, de la Chapelle A
Abstract excerpt
The gene for Progressive myoclonus epilepsy of Unverricht-Lundborg type (EPM1) has previously been mapped by linkage to markers on chromosome 21q22.3. By analyzing crossover events in multiplex disease families with newly detected markers from the region we were able to narrow the localization of...
Topics
- Alleles
- Base Sequence
- Child
- Chromosome Mapping
- Chromosomes, Human, Pair 21
- DNA Primers
- DNA, Satellite
- Epilepsies, Myoclonic
- Female
- Haplotypes
- Humans
- Linkage Disequilibrium
- Male
- Molecular Sequence Data
- Nuclear Family