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Article

Comparative effects of aprotinin and human recombinant R24K KD1 on temporal renal function in Long-Evans rats.

The Journal of pharmacology and experimental therapeutics - 1 Dec 2009

Kempaiah Prakasha, Danielson Leslie A, Barry Marc, Kisiel Walter

Abstract excerpt

Bovine aprotinin, a reversible inhibitor of plasmin and kallikrein, has been clinically approved for over two decades to prevent perioperative blood loss during cardiac surgery. However, because of postoperative renal dysfunction in thousands of these patients, aprotinin was voluntarily withdrawn from the market. Our earlier studies indicated that a R24K mutant of the first Kunitz-type domain of human tissue...

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Identifiers

PMID: 19776384
DOI: 10.1124/jpet.109.161034
PMCID: PMC2784715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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