Article
Adenovirus-Mediated Delivery of Human Kallistatin Gene Reduces Blood Pressure of Spontaneously Hypertensive Rats
10 Feb 1997
Abstract excerpt
Human kallistatin, or human tissue kallikrein-binding protein (HKBP), is a serine proteinase inhibitor (serpin). Transgenic mice overexpressing rat kallikrein-binding protein are hypotensive. To elucidate therapeutic potentials of kallistatin in hypertension, the human kallistatin gene in an adenoviral vector was directly introduced into spontaneously hypertensive rats (SHR) through portal vein injection. The...