Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of RhoB expression enhances the myelodysplastic phenotype of mammalian diaphanous-related Formin mDia1 knockout mice.

PloS one - 21 Sept 2009

DeWard Aaron D, Leali Kellie, West Richard A, Prendergast George C, Alberts Arthur S

Abstract excerpt

Myelodysplastic syndrome (MDS) is characterized by ineffective hematopoiesis and hyperplastic bone marrow. Complete loss or interstitial deletions of the long arm of chromosome 5 occur frequently in MDS. One candidate tumor suppressor on 5q is the mammalian Diaphanous (mDia)-related formin mDia1, encoded by DIAPH1 (5q31.3). mDia-family formins act as effectors for Rho-family small GTP-binding proteins including...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow Cells
Share to Fetal Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Formins

Share to Hematopoietic Stem Cells

Share to Microfilament Proteins

Share to Monocytes

Share to Myelodysplastic Syndromes

Share to Spleen

Source

Open in PubMed Open full text

Identifiers

PMID: 19768111
DOI: 10.1371/journal.pone.0007102
PMCID: PMC2740832

Genes

DIAPH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of RhoB expression enhances the myelodysplastic phenotype of mammalian diaphanous-related Formin mDia1 knockout mice.PMID 19768111Read ↗

Myeloproliferative Defects following Targeting of the Drf1 Gene Encoding the Mammalian Diaphanous–Related Formin mDia1Semantic proximity Read ↗

DIAPH1 mutations predict a favorable outcome for de novo MDS.Semantic proximity Read ↗

Aberrant overexpression of CD14 on granulocytes sensitizes the innate immune response in mDia1 heterozygous del(5q) MDSSemantic proximity Read ↗

Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3zeta.Semantic proximity Read ↗

Impaired function of primitive hematopoietic cells in mice lacking the Mixed-Lineage-Leukemia homolog MLL5.Semantic proximity Read ↗

Rheb1 loss leads to increased hematopoietic stem cell proliferation and myeloid-biased differentiation in vivoSemantic proximity Read ↗

Loss of MLL5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation.Semantic proximity Read ↗

Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype.Semantic proximity Read ↗

Ectopic expression of C/EBP and ID1 is sufficient to restore defective neutrophil development in low-risk myelodysplasiaSemantic proximity Read ↗

Expression of the runt homology domain of RUNX1 disrupts homeostasis of hematopoietic stem cells and induces progression to myelodysplastic syndromeSemantic proximity Read ↗

TGFβ-activated kinase-1 knockdown in hematopoietic stem-progenitor cells causes PANoptosis and myelodysplastic syndrome-like disease in mice.Semantic proximity Read ↗

T Cell Responses in Mammalian Diaphanous-related Formin mDia1 Knock-out MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.