Article
Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype.
Nature medicine - 1 Jan 2010
Starczynowski Daniel T, Kuchenbauer Florian, Argiropoulos Bob, Sung Sandy, Morin Ryan, Muranyi Andrew, Hirst Martin, Hogge Donna, Marra Marco, Wells Richard A, Buckstein Rena, Lam Wan, Humphries R Keith, Karsan Aly
Abstract excerpt
5q- syndrome is a subtype of myelodysplastic syndrome characterized by severe anemia and variable neutropenia but normal or high platelet counts with dysplastic megakaryocytes. We examined expression of microRNAs (miRNAs) encoded on chromosome 5q as a possible cause of haploinsufficiency. We show that deletion of chromosome 5q correlates with loss of two miRNAs that are abundant in hematopoietic stem/progenitor...
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