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Article

Ectopic expression of C/EBP and ID1 is sufficient to restore defective neutrophil development in low-risk myelodysplasia

30 Jul 2009

Abstract excerpt

BACKGROUND: In patients with myelodysplasia, a general defect in the multipotent stem-cell compartment results in disturbed proliferation and differentiation of the erythroid, megakaryocytic and myeloid lineages. Although a number of genetic defects in myelodysplastic progenitor cells have been described, the intracellular signaling pathways underlying aberrant regulation of myelopoiesis remain relatively...

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PMID: 19644139
DOI: 10.3324/haematol.2008.000471

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