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Article

T Cell Responses in Mammalian Diaphanous-related Formin mDia1 Knock-out Mice

27 Jun 2007

Abstract excerpt

Activated T cells rapidly assemble filamentous (F-) actin networks in response to ligation of the T cell receptor or upon interaction with adhesive stimuli in order to facilitate cell migration and the formation of the immune synapse. Branched filament assembly is crucial for this process and is dependent upon activation of the Arp2/3 complex by the actin nucleation-promoting factor Wiskott-Aldrich Syndrome...

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PMID: 17595162
DOI: 10.1074/jbc.m703243200

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