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Article

An objective assessment of conformational variability in complexes of hepatitis C virus polymerase with non-nucleoside inhibitors.

Journal of molecular biology - 2 Dec 2011

Caillet-Saguy Célia, Simister Philip C, Bressanelli Stéphane

Abstract excerpt

A major target for antiviral therapy against hepatitis C virus (HCV) is the HCV polymerase nonstructural protein 5B (NS5B). Huge efforts have been devoted to the development of nucleoside and non-nucleoside inhibitors (NNIs) of NS5B. An offshoot of these efforts has been the structural characterization of the interaction of NS5B with NNIs by X-ray crystallography. These works have shown that the conformation of...

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Identifiers

PMID: 22008450
DOI: 10.1016/j.jmb.2011.10.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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