Article
Changes in T cell phenotype and activated MAPKs are correlated to impaired cellular responses to antigens and glucocorticoids during HTLV-I infection.
Journal of neuroimmunology - 30 Nov 2009
Pillat Micheli M, Correa Bruna L, da Rocha Cláudio F K, Müller Guilherme C, Lopes Rodrigo P, Lampert Simone S, Teixeira Antônio L, Menna-Barreto Márcio, Bauer Moisés E
Abstract excerpt
Lymphocytes of human T-lymphotropic virus type-I (HTLV-I) infected patients were previously found tolerant to mitogenic stimuli as well as glucocorticoid treatment. These data suggest that common signaling events are impaired during this infection. The underlying mechanisms of these phenomena may include changes in cellular composition, cytokine milieu and the differential activation of mitogen-activated protein...
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