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Article

HIV-induced type I interferon and tryptophan catabolism drive T cell dysfunction despite phenotypic activation.

PloS one - 13 Aug 2008

Boasso Adriano, Hardy Andrew W, Anderson Stephanie A, Dolan Matthew J, Shearer Gene M

Abstract excerpt

Infection by the human immunodeficiency virus (HIV) is characterized by functional impairment and chronic activation of T lymphocytes, the causes of which are largely unexplained. We cultured peripheral blood mononuclear cells (PBMC) from HIV-uninfected donors in the presence or absence of HIV. HIV exposure increased expression of the activation markers CD69 and CD38 on CD4 and CD8 T cells. IFN-alpha/beta,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18698365
DOI: 10.1371/journal.pone.0002961
PMCID: PMC2491901

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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