Article
T cells from burn-injured mice demonstrate a loss of sensitivity to glucocorticoids.
American journal of physiology. Endocrinology and metabolism - 1 Aug 2010
D'Elia Michele, Patenaude Julie, Dupras Charles, Bernier Jacques
Abstract excerpt
Glucocorticoids (GC) are steroid hormones that modulate T cell functions and restrain their hyperresponsiveness following stimulation. Naive T lymphocytes are sensitive to GC but become more resistant when they are activated. A balance between activation and inhibition signals is important for a...
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