Article
Induction of resistance to 2',2'-difluorodeoxycytidine in the human ovarian cancer cell line A2780.
Seminars in oncology - 1 Aug 1995
Ruiz van Haperen V W, Veerman G, Eriksson S, Stegmann A P, Peters G J
Abstract excerpt
2',2'-Difluorodeoxycytidine (gemcitabine; dFdC) is a nucleoside analog with promising antitumor activity. To be active it must be phosphorylated by deoxycytidine kinase (dCK). We induced resistance to gemcitabine in the human ovarian carcinoma cell line A2780 by exposure to increasing concentrations of gemcitabine. At 72 hours' exposure the IC50, defined as the concentration of gemcitabine causing 50% growth...
Topics
- Antibiotics, Antineoplastic
- Antimetabolites, Antineoplastic
- Antineoplastic Agents, Phytogenic
- Base Sequence
- Cell Division
- Cytidine Deaminase
- Deoxycytidine
- Deoxycytidine Kinase
- Dose-Response Relationship, Drug
- Doxorubicin