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Article

Amplification of chromosomal segment 4q12 in non-small cell lung cancer.

Cancer biology & therapy - 1 Nov 2009

Ramos Alex H, Dutt Amit, Mermel Craig, Perner Sven, Cho Jeonghee, Lafargue Christopher J, Johnson Laura A, Stiedl Ann-Cathrin, Tanaka Kumiko E, Bass Adam J, Barretina Jordi, Weir Barbara A, Beroukhim Rameen, Thomas Roman K, Minna John D, Chirieac Lucian R, Lindeman Neal I, Giordano Thomas, Beer David G, Wagner Patrick, Wistuba Ignacio I, Rubin Mark A, Meyerson Matthew

Abstract excerpt

In cancer, proto-oncogenes are often altered by genomic amplification. Here we report recurrent focal amplifications of chromosomal segment 4q12 overlapping the proto-oncogenes PDGFRA and KIT in non-small cell lung cancer (NSCLC). Single nucleotide polymorphism (SNP) array and fluorescent in situ hybridization (FISH) analysis indicate that 4q12 is amplified in 3-7% of lung adenocarcinomas and 8-10% of lung...

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Share to Carcinoma, Non-Small-Cell Lung
Share to Chromosomes, Human, Pair 4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19755855
DOI: 10.4161/cbt.8.21.9764
PMCID: PMC2833355

Genes

KIT
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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