Article
CCM2 mediates death signaling by the TrkA receptor tyrosine kinase.
Neuron - 10 Sept 2009
Harel Liraz, Costa Barbara, Tcherpakov Marianna, Zapatka Marc, Oberthuer Andre, Hansford Loen M, Vojvodic Milijana, Levy Zehava, Chen Zhe-Yu, Lee Francis S, Avigad Smadar, Yaniv Isaac, Shi Leming, Eils Roland, Fischer Matthias, Brors Benedikt, Kaplan David R, Fainzilber Mike
Abstract excerpt
The TrkA receptor tyrosine kinase is crucial for differentiation and survival of nerve-growth-factor-dependent neurons. Paradoxically, TrkA also induces cell death in pediatric tumor cells of neural origin, via an unknown mechanism. Here, we show that CCM2, a gene product associated with cerebral cavernous malformations, interacts with the juxtamembrane region of TrkA via its phosphotyrosine binding (PTB) domain...
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