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Article

Live or let die: CCM2 provides the link.

Neuron - 10 Sept 2009

Gruber-Olipitz Mariella, Segal Rosalind A

Abstract excerpt

TrkA receptors are well known for promoting neuronal cell survival. However, in some neuroblastic tumors, TrkA activation can instead induce apoptosis. In this issue of Neuron, Harel et al. identify CCM2 as a mediator of TrkA-dependent cell death, suggesting that CCM2 is a distinctive type of tumor suppressor that modulates tyrosine kinase signaling.

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Source

Identifiers

PMID: 19755097
DOI: 10.1016/j.neuron.2009.08.030

Genes

CCM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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