Article
HLA phenotypes and gene polymorphisms in juvenile liver disease associated with alpha 1-antitrypsin deficiency.
Hepatology (Baltimore, Md.) - 1 Aug 1990
Doherty D G, Donaldson P T, Whitehouse D B, Mieli-Vergani G, Duthie A, Hopkinson D A, Mowat A P
Abstract excerpt
Chronic liver disease affects up to 20% of children with alpha 1-antitrypsin deficiency owing to the PiZZ genotype. Previous observations of a familial occurrence and abnormal immune responses to liver antigens in these patients suggests that immunoregulatory genes may be involved in the pathogenesis of liver damage. We have identified HLA phenotypes and class II (HLA-DR) gene polymorphisms in 140 white PiZZ...
Topics
- Adolescent
- Adult
- Child
- Child, Preschool
- Female
- HLA Antigens
- Humans
- Infant
- Infant, Newborn
- Liver Diseases
- Male
- Phenotype