Article
Genetic polymorphisms in oxidative stress-related genes are associated with outcomes following treatment for aggressive B-cell non-Hodgkin lymphoma.
American journal of hematology - 1 Jun 2014
Gustafson Heather L, Yao Song, Goldman Bryan H, Lee Kristy, Spier Catherine M, LeBlanc Michael L, Rimsza Lisa M, Cerhan James R, Habermann Thomas M, Link Brian K, Maurer Matthew J, Slager Susan L, Persky Daniel O, Miller Thomas P, Fisher Richard I, Ambrosone Christine B, Briehl Margaret M
Abstract excerpt
Variable survival outcomes are seen following treatment for aggressive non-Hodgkin lymphoma (NHL). This study examined whether outcomes for aggressive B-cell NHL are associated with single nucleotide polymorphisms (SNPs) in oxidative stress-related genes, which can alter drug metabolism and immune responses. Genotypes for 53 SNPs in 29 genes were determined for 337 patients given anthracycline-based therapies....
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