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Article

MPO Promoter Polymorphism rs2333227 Enhances Malignant Phenotypes of Colorectal Cancer by Altering the Binding Affinity of AP-2α.

Cancer research - 15 May 2018

Meng Qingtao, Wu Shenshen, Wang Yajie, Xu Jin, Sun Hao, Lu Runze, Gao Na, Yang Hongbao, Li Xiaobo, Tang Boping, Aschner Michael, Chen Rui

Abstract excerpt

Myeloperoxidase (MPO) promoter SNPs rs2243828 (-764T>C) and rs2333227 (G-463A) program malignant phenotypes by regulating MPO transcriptional activity. In this study, we enrolled a total of 1,175 controls and 1,078 patients with colorectal cancer with comprehensive clinical and survival information to assess whether these SNPs could affect the susceptibility and development of colorectal cancer. The MPO rs2333227...

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Source

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Identifiers

PMID: 29540402
DOI: 10.1158/0008-5472.CAN-17-2538
PMCID: PMC6084780

Genes

MPO
MMP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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