Article
Risk of malignant pleural mesothelioma and polymorphisms in genes involved in the genome stability and xenobiotics metabolism.
Mutation research - 1 Dec 2009
Gemignani Federica, Neri Monica, Bottari Fabio, Barale Roberto, Canessa Pier Aldo, Canzian Federico, Ceppi Marcello, Spitaleri Irene, Cipollini Monica, Ivaldi Gian Paolo, Mencoboni Manlio, Scaruffi Paola, Tonini Gian Paolo, Ugolini Donatella, Mutti Luciano, Bonassi Stefano, Landi Stefano
Abstract excerpt
Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer mostly attributable to asbestos exposure. Many polymorphic genes encoding for xenobiotic and oxidative metabolism enzymes (XME) or involved in genome stability (GS) can modulate individual MPM risk in exposed populations. An association study was carried out in a case-control setting including 119 MPM patients and two groups of referent subjects...
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