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Article

Changes in electrostatic surface potential of Na+/K+-ATPase cytoplasmic headpiece induced by cytoplasmic ligand(s) binding.

Biophysical journal - 16 Sept 2009

Kubala Martin, Grycova Lenka, Lansky Zdenek, Sklenovsky Petr, Janovska Marika, Otyepka Michal, Teisinger Jan

Abstract excerpt

A set of single-tryptophan mutants of the Na(+)/K(+)-ATPase isolated, large cytoplasmic loop connecting transmembrane helices M4 and M5 (C45) was prepared to monitor effects of the natural cytoplasmic ligands (i.e., Mg(2+) and/or ATP) binding. We introduced a novel method for the monitoring of the changes in the electrostatic surface potential (ESP) induced by ligand binding, using the quenching of the intrinsic...

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Identifiers

PMID: 19751681
DOI: 10.1016/j.bpj.2009.07.002
PMCID: PMC2741587

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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