Article
Membrane-bound peptides mimicking transmembrane Vph1p helix 7 of yeast V-ATPase: a spectroscopic and polarity mismatch study.
Biochimica et biophysica acta - 15 Oct 2005
Hesselink Renske W, Koehorst Rob B M, Nazarov Petr V, Hemminga Marcus A
Abstract excerpt
The V-ATPases are a family of ATP-dependent proton pumps, involved in a variety of cellular processes, including bone breakdown. V-ATPase enzymes that are too active in the latter process can result in osteoporosis, and inhibitors of the enzyme could be used to treat this disease. As a first step in studying the structure and function of the membrane-embedded interface at which proton translocation takes place,...
Topics
- Acrylamide
- Amino Acid Sequence
- Amino Acids
- Arginine
- Cell Membrane
- Circular Dichroism
- Electron Spin Resonance Spectroscopy
- Histidine
- Lipid Bilayers
- Lipids
- Models, Statistical
- Molecular Sequence Data
- Mutation