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Article

Roles of long-range electrostatic domain interactions and K+ in phosphoenzyme transition of Ca2+-ATPase.

The Journal of biological chemistry - 12 Jul 2013

Yamasaki Kazuo, Daiho Takashi, Danko Stefania, Suzuki Hiroshi

Abstract excerpt

Sarcoplasmic reticulum Ca(2+)-ATPase couples the motions and rearrangements of three cytoplasmic domains (A, P, and N) with Ca(2+) transport. We explored the role of electrostatic force in the domain dynamics in a rate-limiting phosphoenzyme (EP) transition by a systematic approach combining electrostatic screening with salts, computer analysis of electric fields in crystal structures, and mutations. Low KCl...

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Identifiers

PMID: 23737524
DOI: 10.1074/jbc.M113.482711
PMCID: PMC3711328

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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