Article
Transactivation activity of LBP-1 proteins and their dimerization in living cells.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Oct 2009
Katsura Ayako, Kimura Kota, Hosoi Kentaro, Tomokuni Yosuke, Nesori Masanori, Goryo Kenji, Numayama-Tsuruta Keiko, Torii Satoru, Yasumoto Ken-Ichi, Gotoh Osamu, Takada Mamiko, Fukumura Hiroshi, Sogawa Kazuhiro
Abstract excerpt
LBP-1 proteins form dimers and act as transcription factors that activate a number of genes related to cell growth and differentiation. LBP-1a and LBP-1c are localized in the cytoplasm when transiently expressed in cultured cells, but translocated into the nucleus after forming heterodimers with LBP-1b, which is a splicing variant of LBP-1a with an intrinsic nuclear localization signal (NLS). Here, we report that...
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