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Article

Iba1 is an actin-cross-linking protein in macrophages/microglia.

Biochemical and biophysical research communications - 17 Aug 2001

Sasaki Y, Ohsawa K, Kanazawa H, Kohsaka S, Imai Y

Abstract excerpt

Iba1 is a 17-kDa EF hand protein that is specifically expressed in macrophages/microglia and is upregulated during the activation of these cells. When exposed to macrophage colony-stimulating factor (M-CSF), microglia cell line MG5 immediately produces intense membrane ruffles in which Iba1 accumulates together with filamentous actin. In this study, we investigated the physical interaction between Iba1 and actin...

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Identifiers

PMID: 11500035
DOI: 10.1006/bbrc.2001.5388

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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