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The action of HIF-3α variants on HIF-2α-HIF-1β heterodimer formation is directly probed in live cells.

Experimental cell research - 15 Aug 2015

Kim Seong Ho, Hwang Dohyeon, Park Hyunsung, Yang Eun Gyeong, Chung Hak Suk, Kim So Yeon

Abstract excerpt

Hypoxia-inducible factors (HIFs), consisting of α and β subunits, activate various genes to adapt to low oxygen environments through their heterodimeric complex formation in the nucleus. While most of the studies have been extensively focused on the HIF-1α isoform, the effect of HIF-α isoforms on the complex formation between HIF-2α and HIF-1β in live cells has not been reported in detail. To probe these...

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PMID: 26160453
DOI: 10.1016/j.yexcr.2015.06.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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