Article
A myosin-like dimerization helix and an extra-large homeodomain are essential elements of the tripartite DNA binding structure of LFB1.
Cell - 29 Jun 1990
Nicosia A, Monaci P, Tomei L, De Francesco R, Nuzzo M, Stunnenberg H, Cortese R
Abstract excerpt
The transcription activator LFB1 is a major determinant of hepatocyte-specific expression of many genes. To study the mechanisms underlying LFB1 transcriptional selectivity, we have initiated its biochemical characterization. By in vitro complementation assays we have defined two distinct regions...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Binding Sites
- Chromosome Deletion
- DNA-Binding Proteins
- Genetic Complementation Test
- Hepatocyte Nuclear Factor 1
- Hepatocyte Nuclear Factor 1-alpha
- Hepatocyte Nuclear Factor 1-beta
- Macromolecular Substances
- Molecular Sequence Data
- Mutation
- Myocardium