Article
Instability of Foxp3 expression limits the ability of induced regulatory T cells to mitigate graft versus host disease.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2011
Beres Amy, Komorowski Richard, Mihara Masahiko, Drobyski William R
Abstract excerpt
PURPOSE: Graft versus host disease (GVHD) is the major complication of allogeneic bone marrow transplantation (BMT) and limits the therapeutic efficacy of this modality. Although the role of natural T-regulatory cells (nTreg) in attenuating GVHD has been extensively examined, the ability of induced T-regulatory cells (iTreg) to mitigate GVHD is unknown. The purpose of this study was to examine the ability of in...
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