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Article

<i>Tbx1</i> Regulates Proliferation and Differentiation of Multipotent Heart Progenitors

11 Sept 2009

Abstract excerpt

RATIONALE: TBX1 encodes a T-box transcription factor implicated in DiGeorge syndrome, which affects the development of many organs, including the heart. Loss of Tbx1 results into hypoplasia of heart regions derived from the second heart field, a population of cardiac progenitors cells (CPCs). Thus, we hypothesized that Tbx1 is an important player in the biology of CPCs. OBJECTIVE: We asked whether Tbx1 is...

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PMID: 19745164
DOI: 10.1161/circresaha.109.200295

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