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Article

Partial rescue of the Tbx1 mutant heart phenotype by Fgf8: genetic evidence of impaired tissue response to Fgf8.

Journal of molecular and cellular cardiology - 1 Nov 2010

Vitelli Francesca, Lania Gabriella, Huynh Tuong, Baldini Antonio

Abstract excerpt

Tbx1 is the candidate gene of DiGeorge syndrome and is required in humans and mice for the development of the cardiac outflow tract (OFT) and aortic arch arteries. Loss of function mutants present with reduced cell proliferation and premature differentiation of cardiac progenitor cells of the sec...

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Identifiers

PMID: 20807544
DOI: 10.1016/j.yjmcc.2010.08.023
PMCID: PMC2981862

Genes

SHF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20807544-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Partial rescue of the Tbx1 mutant heart phenotype by Fgf8: genetic evidence of impaired tissue response to Fgf8.PMID 20807544Read ↗

Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract.Semantic proximity Read ↗

Fgf8 expression in the Tbx1 domain causes skeletal abnormalities and modifies the aortic arch but not the outflow tract phenotype of Tbx1 mutants.Semantic proximity Read ↗

<i>Tbx1</i> regulates extracellular matrix-cell interactions in the second heart fieldSemantic proximity Read ↗

22q11 deletion syndrome: a role for TBX1 in pharyngeal and cardiovascular development.Semantic proximity Read ↗

<i>Tbx1</i> Regulates Proliferation and Differentiation of Multipotent Heart ProgenitorsSemantic proximity Read ↗

Biallelic expression of Tbx1 protects the embryo from developmental defects caused by increased receptor tyrosine kinase signaling.Semantic proximity Read ↗

Tbx1 regulates extracellular matrix-cell interactions in the second heart fieldSemantic proximity Read ↗

Prdm1 functions in the mesoderm of the second heart field, where it interacts genetically with Tbx1, during outflow tract morphogenesis in the mouse embryo.Semantic proximity Read ↗

Tbx1 coordinates addition of posterior second heart field progenitor cells to the arterial and venous poles of the heart.Semantic proximity Read ↗

Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factors.Semantic proximity Read ↗

An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation.Semantic proximity Read ↗

A phenotypic rescue approach identifies lineage regionalization defects in a mouse model of DiGeorge syndromeSemantic proximity Read ↗

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