Article

A phenotypic rescue approach identifies lineage regionalization defects in a mouse model of DiGeorge syndrome

2021-12-07

Abstract excerpt

<h4>ABSTRACT</h4> TBX1 is a key regulator of pharyngeal apparatus (PhAp) development. Vitamin B12 treatment partially rescues aortic arch patterning defects of Tbx1 +/- embryos. Here we show that it also improves cardiac outflow tract septation and branchiomeric muscle anomalies of Tbx1 hypomorphic mutants. At molecular level, the in vivo vB12 treatment let us to identify genes that were dysregulated by Tbx1...

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Literature Corpus work: 1f2354f6-e22f-59d9-bc58-ed4aa3ca5b47
DOI: 10.1101/2021.12.07.471208

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