Article
Immunosusceptibility genes in rheumatoid arthritis.
Human immunology - 1 Nov 1996
Sherritt M A, Tait B, Varney M, Kanaan C, Stockman A, Mackay I R, Muirden K, Bernard C C, Rowley M J
Abstract excerpt
The polygenic predisposition to RA is conferred particularly by disease susceptibility sequences in the HVR3 of HLA DRB1 present in those subtypes of DR4 and DR1 that are associated with RA. The aim of this study was to examine predisposing interactions between genes encoding HLA and immunoglobul...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Arthritis, Rheumatoid
- Female
- Genes, Immunoglobulin
- Genes, MHC Class I
- Genotype
- HLA-DQ Antigens
- HLA-DR Antigens
- HLA-DRB1 Chains
- Humans
- Male
- Middle Aged
- Sex Factors