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Article

SIRT1 and CLOCK 3111T> C combined genotype is associated with evening preference and weight loss resistance in a behavioral therapy treatment for obesity.

International journal of obesity (2005) - 1 Nov 2012

Garaulet M, Esteban Tardido A, Lee Y-C, Smith C E, Parnell L D, Ordovás J M

Abstract excerpt

BACKGROUND: A new negative feedback loop has been proposed, which suggests connections between the circadian clock and SIRTUIN1 (SIRT1)-dependent functions associated with cell survival, development and metabolism. OBJECTIVE: To develop a SIRT1 and circadian locomotor output cycles kaput (CLOCK) combined genotype and to assess its associations with the chronotype of subjects and their potential resistance to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22310473
DOI: 10.1038/ijo.2011.270
PMCID: PMC4428942

Genes

SIRT1
CLOCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

SIRT1 and CLOCK 3111T> C combined genotype is associated with evening preference and weight loss resistance in a behavioral therapy treatment for obesity.PMID 22310473Read ↗

Ghrelin, sleep reduction and evening preference: relationships to CLOCK 3111 T/C SNP and weight loss.Semantic proximity Read ↗

CLOCK gene is implicated in weight reduction in obese patients participating in a dietary programme based on the Mediterranean diet.Semantic proximity Read ↗

SIRT1 genetic variation is related to BMI and risk of obesity.Semantic proximity Read ↗

Association Between CLOCK 3111 T/C Polymorphism with Ghrelin, GLP-1, Food Timing, Sleep and Chronotype in Overweight and Obese Iranian AdultsSemantic proximity Read ↗

Evening chronotype associates with obesity in severely obese subjects: interaction with CLOCK 3111T/C.Semantic proximity Read ↗

In Search of New Therapeutic Targets in Obesity Treatment: Sirtuins.Semantic proximity Read ↗

PERIOD2 variants are associated with abdominal obesity, psycho-behavioral factors, and attrition in the dietary treatment of obesity.Semantic proximity Read ↗

SIRT1 gene variants are related to risk of childhood obesity.Semantic proximity Read ↗

Daily Rhythm of Fractal Cardiac Dynamics Links to Weight Loss Resistance: Interaction with CLOCK 3111T/C Genetic Variant.Semantic proximity Read ↗

Physical activity and sex modulate obesity risk linked to 3111T/C gene variant of the CLOCK gene in an elderly population: the SUN Project.Semantic proximity Read ↗

CLOCK 3111 T/C SNP interacts with emotional eating behavior for weight-loss in a Mediterranean population.Semantic proximity Read ↗

Polymorphism in the CLOCK gene may influence the effect of fat intake reduction on weight loss.Semantic proximity Read ↗

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