Article
Clinical efficacy of direct DNA sequencing analysis on sputum specimens for early detection of drug-resistant Mycobacterium tuberculosis in a clinical setting.
Chest - 1 Feb 2010
Choi Jeong-Hee, Lee Kyung Wha, Kang Hye-Ryun, Hwang Yong Il, Jang SeungHun, Kim Dong-Gyu, Kim Cheol-Hong, Hyun In-Gyu, Shin Tae-Rim, Park Sang-Myeon, Lee Myung-Goo, Lee Chang-Youl, Park Yong-Bum, Jung Ki-Suck
Abstract excerpt
BACKGROUND: Early detection of drug-resistant Mycobacterium tuberculosis is important for the control and prevention of disease transmission. However, conventional drug susceptibility tests for drug-resistant M tuberculosis take at least 3 to 8 weeks. Here, we report the clinical efficacy of direct DNA sequencing analysis for detecting drug-resistant TB on sputum specimens in a clinical setting. METHODS: A total...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Amidohydrolases
- Bacterial Proteins
- Catalase
- DNA Mutational Analysis
- DNA, Bacterial
- DNA-Directed RNA Polymerases