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Direct Detection of Rifampin-ResistantMycobacterium tuberculosisin Respiratory Specimens by PCR-DNA Sequencing

1 Oct 2004

Abstract excerpt

This study evaluated the feasibility of a molecular strategy based on identification of Mycobacterium tuberculosis by IS6110 PCR or Cobas Amplicor PCR, and rpoB PCR-DNA sequencing of the 81-bp rifampin resistance determining region (RRDR) for direct detection of rifampin resistance in respiratory specimens. A collection of 2,138 respiratory specimens and 352 nonduplicate M. tuberculosis isolates (including 233...

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PMID: 15472290
DOI: 10.1128/jcm.42.10.4438-4443.2004

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